Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal.
Identifieur interne : 000066 ( Main/Exploration ); précédent : 000065; suivant : 000067Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal.
Auteurs : Tobias Baumann [Allemagne] ; Andreas Dunkel [Allemagne] ; Christian Schmid [Allemagne] ; Sabine Schmitt [Allemagne] ; Michael Hiltensperger [Allemagne] ; Kerstin Lohr [Allemagne] ; Vibor Laketa [Allemagne] ; Sainitin Donakonda [Allemagne] ; Uwe Ahting [Allemagne] ; Bettina Lorenz-Depiereux [Allemagne] ; Jan E. Heil [Allemagne] ; Johann Schredelseker [Allemagne] ; Luca Simeoni [Allemagne] ; Caroline Fecher [Allemagne] ; Nina Körber [Allemagne] ; Tanja Bauer [Allemagne] ; Norbert Hüser [Allemagne] ; Daniel Hartmann [Allemagne] ; Melanie Laschinger [Allemagne] ; Kilian Eyerich [Allemagne] ; Stefanie Eyerich [Allemagne] ; Martina Anton [Allemagne] ; Matthew Streeter [États-Unis] ; Tina Wang [États-Unis] ; Burkhart Schraven [Allemagne] ; David Spiegel [États-Unis] ; Farhah Assaad [Allemagne] ; Thomas Misgeld [Allemagne] ; Hans Zischka [Allemagne] ; Peter J. Murray [Allemagne] ; Annkristin Heine [Allemagne] ; Mathias Heikenw Lder [Allemagne] ; Thomas Korn [Allemagne] ; Corinna Dawid [Allemagne] ; Thomas Hofmann [Allemagne] ; Percy A. Knolle [Allemagne] ; Bastian Höchst [Allemagne]Source :
- Nature immunology [ 1529-2916 ] ; 2020.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (MeSH), Amine oxidase (copper-containing) (métabolisme), Animaux (MeSH), Cellules myéloïdes suppressives (immunologie), Communication cellulaire (MeSH), Humains (MeSH), Immunothérapie (méthodes), Lymphocytes T CD8+ (immunologie), Lymphocytes T CD8+ (transplantation), Mélanome (immunologie), Mélanome expérimental (MeSH), Méthylglyoxal (métabolisme), Prolifération cellulaire (MeSH), Récepteur-1 de mort cellulaire programmée (métabolisme), Souris (MeSH), Souris transgéniques (MeSH), Tolérance immunitaire (MeSH), Tumeurs expérimentales (MeSH).
- MESH :
- immunologie : Cellules myéloïdes suppressives, Lymphocytes T CD8+, Mélanome.
- métabolisme : Amine oxidase (copper-containing), Méthylglyoxal, Récepteur-1 de mort cellulaire programmée.
- méthodes : Immunothérapie.
- transplantation : Activation des lymphocytes, Animaux, Communication cellulaire, Humains, Lymphocytes T CD8+, Mélanome expérimental, Prolifération cellulaire, Souris, Souris transgéniques, Tolérance immunitaire, Tumeurs expérimentales.
English descriptors
- KwdEn :
- Amine Oxidase (Copper-Containing) (metabolism), Animals (MeSH), CD8-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (transplantation), Cell Communication (MeSH), Cell Proliferation (MeSH), Humans (MeSH), Immune Tolerance (MeSH), Immunotherapy (methods), Lymphocyte Activation (MeSH), Melanoma (immunology), Melanoma, Experimental (MeSH), Mice (MeSH), Mice, Transgenic (MeSH), Myeloid-Derived Suppressor Cells (immunology), Neoplasms, Experimental (MeSH), Programmed Cell Death 1 Receptor (metabolism), Pyruvaldehyde (metabolism).
- MESH :
- chemical , metabolism : Amine Oxidase (Copper-Containing), Programmed Cell Death 1 Receptor, Pyruvaldehyde.
- immunology : CD8-Positive T-Lymphocytes, Melanoma, Myeloid-Derived Suppressor Cells.
- methods : Immunotherapy.
- transplantation : CD8-Positive T-Lymphocytes.
- Animals, Cell Communication, Cell Proliferation, Humans, Immune Tolerance, Lymphocyte Activation, Melanoma, Experimental, Mice, Mice, Transgenic, Neoplasms, Experimental.
Abstract
Regulatory myeloid immune cells, such as myeloid-derived suppressor cells (MDSCs), populate inflamed or cancerous tissue and block immune cell effector functions. The lack of mechanistic insight into MDSC suppressive activity and a marker for their identification has hampered attempts to overcome T cell inhibition and unleash anti-cancer immunity. Here, we report that human MDSCs were characterized by strongly reduced metabolism and conferred this compromised metabolic state to CD8+ T cells, thereby paralyzing their effector functions. We identified accumulation of the dicarbonyl radical methylglyoxal, generated by semicarbazide-sensitive amine oxidase, to cause the metabolic phenotype of MDSCs and MDSC-mediated paralysis of CD8+ T cells. In a murine cancer model, neutralization of dicarbonyl activity overcame MDSC-mediated T cell suppression and, together with checkpoint inhibition, improved the efficacy of cancer immune therapy. Our results identify the dicarbonyl methylglyoxal as a marker metabolite for MDSCs that mediates T cell paralysis and can serve as a target to improve cancer immune therapy.
DOI: 10.1038/s41590-020-0666-9
PubMed: 32327756
Affiliations:
- Allemagne, États-Unis
- Bade-Wurtemberg, Basse-Saxe, Bavière, Connecticut, District de Cologne, District de Haute-Bavière, District de Karlsruhe, Massachusetts, Rhénanie-du-Nord-Westphalie, Saxe-Anhalt
- Bonn, Göttingen, Heidelberg, Magdebourg, Munich
- Université Louis-et-Maximilien de Munich
Links toward previous steps (curation, corpus...)
Le document en format XML
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Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Laketa, Vibor" sort="Laketa, Vibor" uniqKey="Laketa V" first="Vibor" last="Laketa">Vibor Laketa</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases, German Center for Infection Research, Heidelberg University, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Infectious Diseases, German Center for Infection Research, Heidelberg University, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement 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Ahting</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Human Genetics, Stoffwechselzentrum, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Stoffwechselzentrum, Klinikum Rechts der Isar, School of Medicine, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Lorenz Depiereux, Bettina" sort="Lorenz Depiereux, Bettina" uniqKey="Lorenz Depiereux B" first="Bettina" last="Lorenz-Depiereux">Bettina Lorenz-Depiereux</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Human Genetics, Helmholtz Zentrum München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Helmholtz 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Heil</name><affiliation wicri:level="3"><nlm:affiliation>Carl Zeiss Microscopy, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Carl Zeiss Microscopy, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Schredelseker, Johann" sort="Schredelseker, Johann" uniqKey="Schredelseker J" first="Johann" last="Schredelseker">Johann Schredelseker</name><affiliation wicri:level="4"><nlm:affiliation>Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Simeoni, Luca" sort="Simeoni, Luca" uniqKey="Simeoni L" first="Luca" last="Simeoni">Luca Simeoni</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation></author><author><name sortKey="Fecher, Caroline" sort="Fecher, Caroline" uniqKey="Fecher C" first="Caroline" last="Fecher">Caroline Fecher</name><affiliation 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Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hartmann, Daniel" sort="Hartmann, Daniel" uniqKey="Hartmann D" first="Daniel" last="Hartmann">Daniel Hartmann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Laschinger, Melanie" sort="Laschinger, Melanie" uniqKey="Laschinger M" first="Melanie" last="Laschinger">Melanie Laschinger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Eyerich, Kilian" sort="Eyerich, Kilian" uniqKey="Eyerich K" first="Kilian" last="Eyerich">Kilian Eyerich</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergy, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergy, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Eyerich, Stefanie" sort="Eyerich, Stefanie" uniqKey="Eyerich S" first="Stefanie" last="Eyerich">Stefanie Eyerich</name><affiliation wicri:level="3"><nlm:affiliation>Center of Allergy and Environment, TUM and Helmholtz Zentrum München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Allergy and Environment, TUM and Helmholtz Zentrum München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Anton, Martina" sort="Anton, Martina" uniqKey="Anton M" first="Martina" last="Anton">Martina Anton</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Streeter, Matthew" sort="Streeter, Matthew" uniqKey="Streeter M" first="Matthew" last="Streeter">Matthew Streeter</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chemistry, Yale University, New Haven, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry, Yale University, New Haven, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Wang, Tina" sort="Wang, Tina" uniqKey="Wang T" first="Tina" last="Wang">Tina Wang</name><affiliation wicri:level="2"><nlm:affiliation>Broad Institute of Harvard and MIT, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Broad Institute of Harvard and MIT, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Schraven, Burkhart" sort="Schraven, Burkhart" uniqKey="Schraven B" first="Burkhart" last="Schraven">Burkhart Schraven</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation></author><author><name sortKey="Spiegel, David" sort="Spiegel, David" uniqKey="Spiegel D" first="David" last="Spiegel">David Spiegel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chemistry, Yale University, New Haven, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry, Yale University, New Haven, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacology, Yale University, New Haven, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, Yale University, New Haven, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Assaad, Farhah" sort="Assaad, Farhah" uniqKey="Assaad F" first="Farhah" last="Assaad">Farhah Assaad</name><affiliation wicri:level="3"><nlm:affiliation>Research Department Plant Sciences, Center for Life Science, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Department Plant Sciences, Center for Life Science, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Misgeld, Thomas" sort="Misgeld, Thomas" uniqKey="Misgeld T" first="Thomas" last="Misgeld">Thomas Misgeld</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Neuronal Cell Biology, TUM, Munich Cluster for Systems Neurology and German Center for Neurodegenerative Diseases, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuronal Cell Biology, TUM, Munich Cluster for Systems Neurology and German Center for Neurodegenerative Diseases, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Zischka, Hans" sort="Zischka, Hans" uniqKey="Zischka H" first="Hans" last="Zischka">Hans Zischka</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Toxicology and Environmental Hygiene, School of Medicine, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Toxicology and Environmental Hygiene, School of Medicine, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Murray, Peter J" sort="Murray, Peter J" uniqKey="Murray P" first="Peter J" last="Murray">Peter J. Murray</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute of Biochemistry, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Biochemistry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Heine, Annkristin" sort="Heine, Annkristin" uniqKey="Heine A" first="Annkristin" last="Heine">Annkristin Heine</name><affiliation wicri:level="3"><nlm:affiliation>Medical Clinic III for Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medical Clinic III for Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Experimental Immunology, University Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Experimental Immunology, University Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Heikenw Lder, Mathias" sort="Heikenw Lder, Mathias" uniqKey="Heikenw Lder M" first="Mathias" last="Heikenw Lder">Mathias Heikenw Lder</name><affiliation wicri:level="3"><nlm:affiliation>Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Korn, Thomas" sort="Korn, Thomas" uniqKey="Korn T" first="Thomas" last="Korn">Thomas Korn</name><affiliation wicri:level="3"><nlm:affiliation>Department of Experimental Neuroimmunology, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Experimental Neuroimmunology, Klinikum Rechts der Isar, School of Medicine, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Dawid, Corinna" sort="Dawid, Corinna" uniqKey="Dawid C" first="Corinna" last="Dawid">Corinna Dawid</name><affiliation wicri:level="3"><nlm:affiliation>Food Chemistry and Molecular Sensory Science, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Food Chemistry and Molecular Sensory Science, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hofmann, Thomas" sort="Hofmann, Thomas" uniqKey="Hofmann T" first="Thomas" last="Hofmann">Thomas Hofmann</name><affiliation wicri:level="3"><nlm:affiliation>Leibniz-Institute of Food Systems Biology, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Leibniz-Institute of Food Systems Biology, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Food Chemistry and Molecular Sensory Science, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Food Chemistry and Molecular Sensory Science, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Knolle, Percy A" sort="Knolle, Percy A" uniqKey="Knolle P" first="Percy A" last="Knolle">Percy A. Knolle</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany. Percy.Knolle@tum.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular Immunology, School of Life Sciences, TUM, Munich, Germany. Percy.Knolle@tum.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular Immunology, School of Life Sciences, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>German Center for Infection Research, Munich, Germany. Percy.Knolle@tum.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hochst, Bastian" sort="Hochst, Bastian" uniqKey="Hochst B" first="Bastian" last="Höchst">Bastian Höchst</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular Immunology, School of Life Sciences, TUM, Munich, Germany. Bastian.Hoechst@tum.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular Immunology, School of Life Sciences, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32327756</idno><idno type="pmid">32327756</idno><idno type="doi">10.1038/s41590-020-0666-9</idno><idno type="wicri:Area/Main/Corpus">000155</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000155</idno><idno type="wicri:Area/Main/Curation">000155</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000155</idno><idno type="wicri:Area/Main/Exploration">000155</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal.</title><author><name sortKey="Baumann, Tobias" sort="Baumann, Tobias" uniqKey="Baumann T" first="Tobias" last="Baumann">Tobias Baumann</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Dunkel, Andreas" sort="Dunkel, Andreas" uniqKey="Dunkel A" first="Andreas" last="Dunkel">Andreas Dunkel</name><affiliation wicri:level="3"><nlm:affiliation>Leibniz-Institute of Food Systems Biology, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Leibniz-Institute of Food Systems Biology, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Schmid, Christian" sort="Schmid, Christian" uniqKey="Schmid C" first="Christian" last="Schmid">Christian Schmid</name><affiliation wicri:level="3"><nlm:affiliation>Food Chemistry and Molecular Sensory Science, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Food Chemistry and Molecular Sensory Science, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Schmitt, Sabine" sort="Schmitt, Sabine" uniqKey="Schmitt S" first="Sabine" last="Schmitt">Sabine Schmitt</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Toxicology and Environmental Hygiene, School of Medicine, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Toxicology and Environmental Hygiene, School of Medicine, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hiltensperger, Michael" sort="Hiltensperger, Michael" uniqKey="Hiltensperger M" first="Michael" last="Hiltensperger">Michael Hiltensperger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Experimental Neuroimmunology, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Experimental Neuroimmunology, Klinikum Rechts der Isar, School of Medicine, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Lohr, Kerstin" sort="Lohr, Kerstin" uniqKey="Lohr K" first="Kerstin" last="Lohr">Kerstin Lohr</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Laketa, Vibor" sort="Laketa, Vibor" uniqKey="Laketa V" first="Vibor" last="Laketa">Vibor Laketa</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases, German Center for Infection Research, Heidelberg University, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Infectious Diseases, German Center for Infection Research, Heidelberg University, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Donakonda, Sainitin" sort="Donakonda, Sainitin" uniqKey="Donakonda S" first="Sainitin" last="Donakonda">Sainitin Donakonda</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Ahting, Uwe" sort="Ahting, Uwe" uniqKey="Ahting U" first="Uwe" last="Ahting">Uwe Ahting</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Human Genetics, Stoffwechselzentrum, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Stoffwechselzentrum, Klinikum Rechts der Isar, School of Medicine, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Lorenz Depiereux, Bettina" sort="Lorenz Depiereux, Bettina" uniqKey="Lorenz Depiereux B" first="Bettina" last="Lorenz-Depiereux">Bettina Lorenz-Depiereux</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Human Genetics, Helmholtz Zentrum München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Helmholtz Zentrum München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Heil, Jan E" sort="Heil, Jan E" uniqKey="Heil J" first="Jan E" last="Heil">Jan E. Heil</name><affiliation wicri:level="3"><nlm:affiliation>Carl Zeiss Microscopy, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Carl Zeiss Microscopy, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Schredelseker, Johann" sort="Schredelseker, Johann" uniqKey="Schredelseker J" first="Johann" last="Schredelseker">Johann Schredelseker</name><affiliation wicri:level="4"><nlm:affiliation>Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Simeoni, Luca" sort="Simeoni, Luca" uniqKey="Simeoni L" first="Luca" last="Simeoni">Luca Simeoni</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation></author><author><name sortKey="Fecher, Caroline" sort="Fecher, Caroline" uniqKey="Fecher C" first="Caroline" last="Fecher">Caroline Fecher</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Neuronal Cell Biology, TUM, Munich Cluster for Systems Neurology and German Center for Neurodegenerative Diseases, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuronal Cell Biology, TUM, Munich Cluster for Systems Neurology and German Center for Neurodegenerative Diseases, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Korber, Nina" sort="Korber, Nina" uniqKey="Korber N" first="Nina" last="Körber">Nina Körber</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, Helmholtz Zentrum München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Helmholtz Zentrum München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Bauer, Tanja" sort="Bauer, Tanja" uniqKey="Bauer T" first="Tanja" last="Bauer">Tanja Bauer</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, Helmholtz Zentrum München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Helmholtz Zentrum München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Huser, Norbert" sort="Huser, Norbert" uniqKey="Huser N" first="Norbert" last="Hüser">Norbert Hüser</name><affiliation wicri:level="3"><nlm:affiliation>Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hartmann, Daniel" sort="Hartmann, Daniel" uniqKey="Hartmann D" first="Daniel" last="Hartmann">Daniel Hartmann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Laschinger, Melanie" sort="Laschinger, Melanie" uniqKey="Laschinger M" first="Melanie" last="Laschinger">Melanie Laschinger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Eyerich, Kilian" sort="Eyerich, Kilian" uniqKey="Eyerich K" first="Kilian" last="Eyerich">Kilian Eyerich</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergy, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergy, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Eyerich, Stefanie" sort="Eyerich, Stefanie" uniqKey="Eyerich S" first="Stefanie" last="Eyerich">Stefanie Eyerich</name><affiliation wicri:level="3"><nlm:affiliation>Center of Allergy and Environment, TUM and Helmholtz Zentrum München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Allergy and Environment, TUM and Helmholtz Zentrum München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Anton, Martina" sort="Anton, Martina" uniqKey="Anton M" first="Martina" last="Anton">Martina Anton</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Streeter, Matthew" sort="Streeter, Matthew" uniqKey="Streeter M" first="Matthew" last="Streeter">Matthew Streeter</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chemistry, Yale University, New Haven, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry, Yale University, New Haven, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Wang, Tina" sort="Wang, Tina" uniqKey="Wang T" first="Tina" last="Wang">Tina Wang</name><affiliation wicri:level="2"><nlm:affiliation>Broad Institute of Harvard and MIT, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Broad Institute of Harvard and MIT, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Schraven, Burkhart" sort="Schraven, Burkhart" uniqKey="Schraven B" first="Burkhart" last="Schraven">Burkhart Schraven</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation></author><author><name sortKey="Spiegel, David" sort="Spiegel, David" uniqKey="Spiegel D" first="David" last="Spiegel">David Spiegel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chemistry, Yale University, New Haven, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry, Yale University, New Haven, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacology, Yale University, New Haven, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, Yale University, New Haven, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Assaad, Farhah" sort="Assaad, Farhah" uniqKey="Assaad F" first="Farhah" last="Assaad">Farhah Assaad</name><affiliation wicri:level="3"><nlm:affiliation>Research Department Plant Sciences, Center for Life Science, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Department Plant Sciences, Center for Life Science, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Misgeld, Thomas" sort="Misgeld, Thomas" uniqKey="Misgeld T" first="Thomas" last="Misgeld">Thomas Misgeld</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Neuronal Cell Biology, TUM, Munich Cluster for Systems Neurology and German Center for Neurodegenerative Diseases, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuronal Cell Biology, TUM, Munich Cluster for Systems Neurology and German Center for Neurodegenerative Diseases, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Zischka, Hans" sort="Zischka, Hans" uniqKey="Zischka H" first="Hans" last="Zischka">Hans Zischka</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Toxicology and Environmental Hygiene, School of Medicine, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Toxicology and Environmental Hygiene, School of Medicine, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Murray, Peter J" sort="Murray, Peter J" uniqKey="Murray P" first="Peter J" last="Murray">Peter J. Murray</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute of Biochemistry, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Biochemistry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Heine, Annkristin" sort="Heine, Annkristin" uniqKey="Heine A" first="Annkristin" last="Heine">Annkristin Heine</name><affiliation wicri:level="3"><nlm:affiliation>Medical Clinic III for Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medical Clinic III for Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Experimental Immunology, University Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Experimental Immunology, University Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Heikenw Lder, Mathias" sort="Heikenw Lder, Mathias" uniqKey="Heikenw Lder M" first="Mathias" last="Heikenw Lder">Mathias Heikenw Lder</name><affiliation wicri:level="3"><nlm:affiliation>Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Korn, Thomas" sort="Korn, Thomas" uniqKey="Korn T" first="Thomas" last="Korn">Thomas Korn</name><affiliation wicri:level="3"><nlm:affiliation>Department of Experimental Neuroimmunology, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Experimental Neuroimmunology, Klinikum Rechts der Isar, School of Medicine, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Dawid, Corinna" sort="Dawid, Corinna" uniqKey="Dawid C" first="Corinna" last="Dawid">Corinna Dawid</name><affiliation wicri:level="3"><nlm:affiliation>Food Chemistry and Molecular Sensory Science, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Food Chemistry and Molecular Sensory Science, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hofmann, Thomas" sort="Hofmann, Thomas" uniqKey="Hofmann T" first="Thomas" last="Hofmann">Thomas Hofmann</name><affiliation wicri:level="3"><nlm:affiliation>Leibniz-Institute of Food Systems Biology, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Leibniz-Institute of Food Systems Biology, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Food Chemistry and Molecular Sensory Science, TUM, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Food Chemistry and Molecular Sensory Science, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Knolle, Percy A" sort="Knolle, Percy A" uniqKey="Knolle P" first="Percy A" last="Knolle">Percy A. Knolle</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany. Percy.Knolle@tum.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular Immunology, School of Life Sciences, TUM, Munich, Germany. Percy.Knolle@tum.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular Immunology, School of Life Sciences, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>German Center for Infection Research, Munich, Germany. Percy.Knolle@tum.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hochst, Bastian" sort="Hochst, Bastian" uniqKey="Hochst B" first="Bastian" last="Höchst">Bastian Höchst</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular Immunology, School of Life Sciences, TUM, Munich, Germany. Bastian.Hoechst@tum.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular Immunology, School of Life Sciences, TUM, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author></analytic><series><title level="j">Nature immunology</title><idno type="eISSN">1529-2916</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amine Oxidase (Copper-Containing) (metabolism)</term><term>Animals (MeSH)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>CD8-Positive T-Lymphocytes (transplantation)</term><term>Cell Communication (MeSH)</term><term>Cell Proliferation (MeSH)</term><term>Humans (MeSH)</term><term>Immune Tolerance (MeSH)</term><term>Immunotherapy (methods)</term><term>Lymphocyte Activation (MeSH)</term><term>Melanoma (immunology)</term><term>Melanoma, Experimental (MeSH)</term><term>Mice (MeSH)</term><term>Mice, Transgenic (MeSH)</term><term>Myeloid-Derived Suppressor Cells (immunology)</term><term>Neoplasms, Experimental (MeSH)</term><term>Programmed Cell Death 1 Receptor (metabolism)</term><term>Pyruvaldehyde (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (MeSH)</term><term>Amine oxidase (copper-containing) (métabolisme)</term><term>Animaux (MeSH)</term><term>Cellules myéloïdes suppressives (immunologie)</term><term>Communication cellulaire (MeSH)</term><term>Humains (MeSH)</term><term>Immunothérapie (méthodes)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Lymphocytes T CD8+ (transplantation)</term><term>Mélanome (immunologie)</term><term>Mélanome expérimental (MeSH)</term><term>Méthylglyoxal (métabolisme)</term><term>Prolifération cellulaire (MeSH)</term><term>Récepteur-1 de mort cellulaire programmée (métabolisme)</term><term>Souris (MeSH)</term><term>Souris transgéniques (MeSH)</term><term>Tolérance immunitaire (MeSH)</term><term>Tumeurs expérimentales (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amine Oxidase (Copper-Containing)</term><term>Programmed Cell Death 1 Receptor</term><term>Pyruvaldehyde</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules myéloïdes suppressives</term><term>Lymphocytes T CD8+</term><term>Mélanome</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>Melanoma</term><term>Myeloid-Derived Suppressor Cells</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunotherapy</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Amine oxidase (copper-containing)</term><term>Méthylglyoxal</term><term>Récepteur-1 de mort cellulaire programmée</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Immunothérapie</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Communication</term><term>Cell Proliferation</term><term>Humans</term><term>Immune Tolerance</term><term>Lymphocyte Activation</term><term>Melanoma, Experimental</term><term>Mice</term><term>Mice, Transgenic</term><term>Neoplasms, Experimental</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="fr"><term>Activation des lymphocytes</term><term>Animaux</term><term>Communication cellulaire</term><term>Humains</term><term>Lymphocytes T CD8+</term><term>Mélanome expérimental</term><term>Prolifération cellulaire</term><term>Souris</term><term>Souris transgéniques</term><term>Tolérance immunitaire</term><term>Tumeurs expérimentales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Regulatory myeloid immune cells, such as myeloid-derived suppressor cells (MDSCs), populate inflamed or cancerous tissue and block immune cell effector functions. The lack of mechanistic insight into MDSC suppressive activity and a marker for their identification has hampered attempts to overcome T cell inhibition and unleash anti-cancer immunity. Here, we report that human MDSCs were characterized by strongly reduced metabolism and conferred this compromised metabolic state to CD8<sup>+</sup> T cells, thereby paralyzing their effector functions. We identified accumulation of the dicarbonyl radical methylglyoxal, generated by semicarbazide-sensitive amine oxidase, to cause the metabolic phenotype of MDSCs and MDSC-mediated paralysis of CD8<sup>+</sup> T cells. In a murine cancer model, neutralization of dicarbonyl activity overcame MDSC-mediated T cell suppression and, together with checkpoint inhibition, improved the efficacy of cancer immune therapy. Our results identify the dicarbonyl methylglyoxal as a marker metabolite for MDSCs that mediates T cell paralysis and can serve as a target to improve cancer immune therapy.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32327756</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>06</Day></DateCompleted><DateRevised><Year>2020</Year><Month>07</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1529-2916</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>5</Issue><PubDate><Year>2020</Year><Month>05</Month></PubDate></JournalIssue><Title>Nature immunology</Title><ISOAbbreviation>Nat Immunol</ISOAbbreviation></Journal><ArticleTitle>Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal.</ArticleTitle><Pagination><MedlinePgn>555-566</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41590-020-0666-9</ELocationID><Abstract><AbstractText>Regulatory myeloid immune cells, such as myeloid-derived suppressor cells (MDSCs), populate inflamed or cancerous tissue and block immune cell effector functions. The lack of mechanistic insight into MDSC suppressive activity and a marker for their identification has hampered attempts to overcome T cell inhibition and unleash anti-cancer immunity. Here, we report that human MDSCs were characterized by strongly reduced metabolism and conferred this compromised metabolic state to CD8<sup>+</sup> T cells, thereby paralyzing their effector functions. We identified accumulation of the dicarbonyl radical methylglyoxal, generated by semicarbazide-sensitive amine oxidase, to cause the metabolic phenotype of MDSCs and MDSC-mediated paralysis of CD8<sup>+</sup> T cells. In a murine cancer model, neutralization of dicarbonyl activity overcame MDSC-mediated T cell suppression and, together with checkpoint inhibition, improved the efficacy of cancer immune therapy. Our results identify the dicarbonyl methylglyoxal as a marker metabolite for MDSCs that mediates T cell paralysis and can serve as a target to improve cancer immune therapy.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Baumann</LastName><ForeName>Tobias</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dunkel</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4445-6144</Identifier><AffiliationInfo><Affiliation>Leibniz-Institute of Food Systems Biology, TUM, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmid</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Food Chemistry and Molecular Sensory Science, TUM, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmitt</LastName><ForeName>Sabine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute for Toxicology and Environmental Hygiene, School of Medicine, TUM, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hiltensperger</LastName><ForeName>Michael</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-4600-1394</Identifier><AffiliationInfo><Affiliation>Department of Experimental Neuroimmunology, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lohr</LastName><ForeName>Kerstin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laketa</LastName><ForeName>Vibor</ForeName><Initials>V</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-9472-2738</Identifier><AffiliationInfo><Affiliation>Department of Infectious Diseases, German Center for Infection Research, Heidelberg University, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Donakonda</LastName><ForeName>Sainitin</ForeName><Initials>S</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-3216-8759</Identifier><AffiliationInfo><Affiliation>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahting</LastName><ForeName>Uwe</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics, Stoffwechselzentrum, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lorenz-Depiereux</LastName><ForeName>Bettina</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics, Helmholtz Zentrum München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heil</LastName><ForeName>Jan E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Carl Zeiss Microscopy, Göttingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schredelseker</LastName><ForeName>Johann</ForeName><Initials>J</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-6657-0466</Identifier><AffiliationInfo><Affiliation>Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simeoni</LastName><ForeName>Luca</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fecher</LastName><ForeName>Caroline</ForeName><Initials>C</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-7179-7323</Identifier><AffiliationInfo><Affiliation>Institute of Neuronal Cell Biology, TUM, Munich Cluster for Systems Neurology and German Center for Neurodegenerative Diseases, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Körber</LastName><ForeName>Nina</ForeName><Initials>N</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0991-6547</Identifier><AffiliationInfo><Affiliation>Institute of Virology, Helmholtz Zentrum München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bauer</LastName><ForeName>Tanja</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Virology, Helmholtz Zentrum München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hüser</LastName><ForeName>Norbert</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hartmann</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laschinger</LastName><ForeName>Melanie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eyerich</LastName><ForeName>Kilian</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Dermatology and Allergy, TUM, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eyerich</LastName><ForeName>Stefanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Center of Allergy and Environment, TUM and Helmholtz Zentrum München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anton</LastName><ForeName>Martina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Streeter</LastName><ForeName>Matthew</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Chemistry, Yale University, New Haven, CT, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Tina</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Broad Institute of Harvard and MIT, Cambridge, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schraven</LastName><ForeName>Burkhart</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spiegel</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Chemistry, Yale University, New Haven, CT, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pharmacology, Yale University, New Haven, CT, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Assaad</LastName><ForeName>Farhah</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Research Department Plant Sciences, Center for Life Science, TUM, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Misgeld</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Neuronal Cell Biology, TUM, Munich Cluster for Systems Neurology and German Center for Neurodegenerative Diseases, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zischka</LastName><ForeName>Hans</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute for Toxicology and Environmental Hygiene, School of Medicine, TUM, Munich, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, Neuherberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murray</LastName><ForeName>Peter J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Max Planck Institute of Biochemistry, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heine</LastName><ForeName>Annkristin</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Medical Clinic III for Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Experimental Immunology, University Bonn, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heikenwälder</LastName><ForeName>Mathias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Korn</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-3633-0955</Identifier><AffiliationInfo><Affiliation>Department of Experimental Neuroimmunology, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dawid</LastName><ForeName>Corinna</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Food Chemistry and Molecular Sensory Science, TUM, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofmann</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Leibniz-Institute of Food Systems Biology, TUM, Munich, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Food Chemistry and Molecular Sensory Science, TUM, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Knolle</LastName><ForeName>Percy A</ForeName><Initials>PA</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-2983-0414</Identifier><AffiliationInfo><Affiliation>Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany. Percy.Knolle@tum.de.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Life Sciences, TUM, Munich, Germany. Percy.Knolle@tum.de.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Center for Infection Research, Munich, Germany. Percy.Knolle@tum.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Höchst</LastName><ForeName>Bastian</ForeName><Initials>B</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-5567-1173</Identifier><AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Life Sciences, TUM, Munich, Germany. Bastian.Hoechst@tum.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Nat Immunol</MedlineTA><NlmUniqueID>100941354</NlmUniqueID><ISSNLinking>1529-2908</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C491383">Pdcd1 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D061026">Programmed Cell Death 1 Receptor</NameOfSubstance></Chemical><Chemical><RegistryNumber>722KLD7415</RegistryNumber><NameOfSubstance UI="D011765">Pyruvaldehyde</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.4.3.21</RegistryNumber><NameOfSubstance UI="D006631">Amine Oxidase (Copper-Containing)</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Nat Immunol. 2020 May;21(5):497-498</RefSource><PMID Version="1">32327751</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Nat Rev Immunol. 2020 Jun;20(6):352-353</RefSource><PMID Version="1">32367052</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D006631" MajorTopicYN="N">Amine Oxidase (Copper-Containing)</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000637" MajorTopicYN="N">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002450" MajorTopicYN="N">Cell Communication</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007108" MajorTopicYN="N">Immune Tolerance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007167" MajorTopicYN="N">Immunotherapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008213" MajorTopicYN="N">Lymphocyte Activation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008545" MajorTopicYN="N">Melanoma</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008546" MajorTopicYN="N">Melanoma, Experimental</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008822" MajorTopicYN="N">Mice, Transgenic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000072737" MajorTopicYN="N">Myeloid-Derived Suppressor Cells</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009374" MajorTopicYN="N">Neoplasms, Experimental</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D061026" MajorTopicYN="N">Programmed Cell Death 1 Receptor</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011765" MajorTopicYN="N">Pyruvaldehyde</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>07</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32327756</ArticleId><ArticleId IdType="doi">10.1038/s41590-020-0666-9</ArticleId><ArticleId IdType="pii">10.1038/s41590-020-0666-9</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>Bavière</li><li>Connecticut</li><li>District de Cologne</li><li>District de Haute-Bavière</li><li>District de Karlsruhe</li><li>Massachusetts</li><li>Rhénanie-du-Nord-Westphalie</li><li>Saxe-Anhalt</li></region><settlement><li>Bonn</li><li>Göttingen</li><li>Heidelberg</li><li>Magdebourg</li><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Baumann, Tobias" sort="Baumann, Tobias" uniqKey="Baumann T" first="Tobias" last="Baumann">Tobias Baumann</name></region><name sortKey="Ahting, Uwe" sort="Ahting, Uwe" uniqKey="Ahting U" first="Uwe" last="Ahting">Uwe Ahting</name><name sortKey="Anton, Martina" sort="Anton, Martina" uniqKey="Anton M" first="Martina" 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first="Caroline" last="Fecher">Caroline Fecher</name><name sortKey="Hartmann, Daniel" sort="Hartmann, Daniel" uniqKey="Hartmann D" first="Daniel" last="Hartmann">Daniel Hartmann</name><name sortKey="Heikenw Lder, Mathias" sort="Heikenw Lder, Mathias" uniqKey="Heikenw Lder M" first="Mathias" last="Heikenw Lder">Mathias Heikenw Lder</name><name sortKey="Heil, Jan E" sort="Heil, Jan E" uniqKey="Heil J" first="Jan E" last="Heil">Jan E. Heil</name><name sortKey="Heine, Annkristin" sort="Heine, Annkristin" uniqKey="Heine A" first="Annkristin" last="Heine">Annkristin Heine</name><name sortKey="Heine, Annkristin" sort="Heine, Annkristin" uniqKey="Heine A" first="Annkristin" last="Heine">Annkristin Heine</name><name sortKey="Hiltensperger, Michael" sort="Hiltensperger, Michael" uniqKey="Hiltensperger M" first="Michael" last="Hiltensperger">Michael Hiltensperger</name><name sortKey="Hochst, Bastian" sort="Hochst, Bastian" uniqKey="Hochst B" first="Bastian" last="Höchst">Bastian Höchst</name><name sortKey="Hofmann, Thomas" sort="Hofmann, Thomas" uniqKey="Hofmann T" first="Thomas" last="Hofmann">Thomas Hofmann</name><name sortKey="Hofmann, Thomas" sort="Hofmann, Thomas" uniqKey="Hofmann T" first="Thomas" last="Hofmann">Thomas Hofmann</name><name sortKey="Huser, Norbert" sort="Huser, Norbert" uniqKey="Huser N" first="Norbert" last="Hüser">Norbert Hüser</name><name sortKey="Knolle, Percy A" sort="Knolle, Percy A" uniqKey="Knolle P" first="Percy A" last="Knolle">Percy A. 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Knolle</name><name sortKey="Korber, Nina" sort="Korber, Nina" uniqKey="Korber N" first="Nina" last="Körber">Nina Körber</name><name sortKey="Korn, Thomas" sort="Korn, Thomas" uniqKey="Korn T" first="Thomas" last="Korn">Thomas Korn</name><name sortKey="Laketa, Vibor" sort="Laketa, Vibor" uniqKey="Laketa V" first="Vibor" last="Laketa">Vibor Laketa</name><name sortKey="Laschinger, Melanie" sort="Laschinger, Melanie" uniqKey="Laschinger M" first="Melanie" last="Laschinger">Melanie Laschinger</name><name sortKey="Lohr, Kerstin" sort="Lohr, Kerstin" uniqKey="Lohr K" first="Kerstin" last="Lohr">Kerstin Lohr</name><name sortKey="Lorenz Depiereux, Bettina" sort="Lorenz Depiereux, Bettina" uniqKey="Lorenz Depiereux B" first="Bettina" last="Lorenz-Depiereux">Bettina Lorenz-Depiereux</name><name sortKey="Misgeld, Thomas" sort="Misgeld, Thomas" uniqKey="Misgeld T" first="Thomas" last="Misgeld">Thomas Misgeld</name><name sortKey="Murray, Peter J" sort="Murray, Peter J" uniqKey="Murray P" first="Peter J" last="Murray">Peter J. Murray</name><name sortKey="Schmid, Christian" sort="Schmid, Christian" uniqKey="Schmid C" first="Christian" last="Schmid">Christian Schmid</name><name sortKey="Schmitt, Sabine" sort="Schmitt, Sabine" uniqKey="Schmitt S" first="Sabine" last="Schmitt">Sabine Schmitt</name><name sortKey="Schraven, Burkhart" sort="Schraven, Burkhart" uniqKey="Schraven B" first="Burkhart" last="Schraven">Burkhart Schraven</name><name sortKey="Schredelseker, Johann" sort="Schredelseker, Johann" uniqKey="Schredelseker J" first="Johann" last="Schredelseker">Johann Schredelseker</name><name sortKey="Simeoni, Luca" sort="Simeoni, Luca" uniqKey="Simeoni L" first="Luca" last="Simeoni">Luca Simeoni</name><name sortKey="Zischka, Hans" sort="Zischka, Hans" uniqKey="Zischka H" first="Hans" last="Zischka">Hans Zischka</name><name sortKey="Zischka, Hans" sort="Zischka, Hans" uniqKey="Zischka H" first="Hans" last="Zischka">Hans Zischka</name></country><country name="États-Unis"><region name="Connecticut"><name sortKey="Streeter, Matthew" sort="Streeter, Matthew" uniqKey="Streeter M" first="Matthew" last="Streeter">Matthew Streeter</name></region><name sortKey="Spiegel, David" sort="Spiegel, David" uniqKey="Spiegel D" first="David" last="Spiegel">David Spiegel</name><name sortKey="Spiegel, David" sort="Spiegel, David" uniqKey="Spiegel D" first="David" last="Spiegel">David Spiegel</name><name sortKey="Wang, Tina" sort="Wang, Tina" uniqKey="Wang T" first="Tina" last="Wang">Tina Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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